Jan-Fiete Arp (8th minute), Nicolas Kuehn (62nd) and Sahverdi Cetin (90+2) netted for the winners, while Ibrahima Soumah got the lone goal for Guinea in the 26th minute in the final Group C match at the Jawaharlal Nehru International Stadium.
The World Cup debutants scored once in each half to win 2-0 and stay in the race for a place in the second round.
Ghana and the United States would look to seal a knockout berth when they face-off in their second group match of the FIFA U-17 World Cup in New Delhi, on Monday.
An inspired performance from Douglas Costa helped Brazil to a 3-0 win over Peru on Tuesday and lifted them into third place in the South American qualifying group for the 2018 World Cup in Russia.
An 85th minute penalty by Asamoah Gyan gave Ghana a 1-0 win over Serbia and Africa its first victory of this World Cup finals on Sunday in a match which brought a true flavour of the continent to the tournament.
India coach Luis Norton de Matos on Sunday said they are ready for a physically and technically superior Colombia and will 'fight till the last minute' in their Group A match of the FIFA U-17 World Cup in New Delhi, on Monday.
Ghana have overcome the hurdle of a captain without a club and the lack of a proven goal scorer to romp to easy World Cup qualification, the first country to book their place from the African qualifiers.
Two-time champions Ghana are seeking to revive their fortunes in the tournament, having last won it way back in 1995, when they stunned a Brazilian outfit that had the likes of Julio Cesar in its ranks.
Follow the Netherlands-Brazil and Ghana-Uruguay quarter-finals at the football Wrodl Cup live.
Live updates of Saturday's World Cup matches.
The complete fixtures of the World Cup in SOuth Africa.
The fixtures of the 2010 FIFA World Cup, in South Africa, from June 11 to July 11.
Midfielder Sulley Muntari could feature in Ghana's opening World Cup Group D match against Serbia on Sunday after recovering from a thigh injury, Ghana Football Association website said on Friday.
The fixtures of the 2010 FIFA World Cup, in South Africa, from June 11 to July 11.
Michael Essien's importance to Ghana cannot be underestimated, leaving the Black Stars on edge as they await a decision on his fitness for the World Cup. The Chelsea midfielder, described by Ghana coach Milovan Rajevac as the leader of his team, has a long-term knee injury and, though he has been named in the preliminary squad, could miss the tournament in South Africa.
With most of his Wigan team-mates already long gone after an energetic end-of-season training session, Richard Kingson walks forlornly from the treatment room towards his car. The Ghana goalkeeper is unsure whether he has a World Cup to look forward to. Kingson, who will be 32 next month, has not played a competitive match since injuring his thigh at the African Cup of Nations in January when he captained Ghana to the final.
Ghana's dreams of becoming the first African side to reach a World Cup semi-final will depend on their ability to keep at bay the formidable attacking duo which has propelled Uruguay into the quarters. The Ghanaians carry the hopes of a continent hosting its first World Cup, but any burden of expectation is far out weighed by the need to keep a close check on the ability of Diego Forlan and Luis Suarez when they meet in their quarter-final tie in Johannesburg.
India's FIFA U-17 World Cup team coach Luis Norton de Matos on Saturday refused to predict his side's chances in the upcoming tournament, saying that instead of thinking about the results the country should take it as "a first step for the future".
Hadji Drame (15th minute) and Djemoussa Traore (61st) scored for Mali, while Kudus Mohammed (70th) scored a consolation goal for Ghana.
Live updates from the matches at the football World Cup in South Africa.
The Africans beat the United States 2-1 in a Group E decider and clinched a place.
Hosts India struggled on their debut as they were outclassed 3-0 by United States in the FIFA Under-17 World Cup Group A match in New Delhi on Friday.
Ghana's national soccer team won a $20,000 cash bonus per player on Tuesday and were hailed moral victors by former U.N. chief and countryman Kofi Annan after losing out on a World Cup semi-final place.
Ghana striker Asamoah Gyan suffered an ankle injury in training on Monday and sat out most of a rigorous two-hour session as Africa's last hopes prepared for Friday's World Cup quarter-final.
He scored his first World Cup goal in 2006 and consistently found the next in consecutive World Cups.
What happened in Bengaluru is a wake-up call, no celebration of sport should ever come at the cost of human life, asserts veteran cricket correspondent K R Nayar.
Claudio Reyna and goalkeeper Kasey Keller became the first Americans to feature in four World Cups when they played at these finals
An 85th minute penalty from Asamoah Gyan gave Ghana a 1-0 victory over Serbia in World Cup Group D on Sunday - providing Africa with their first win in the tournament.
"It's very difficult for us, the probability for us to proceed is lower than the other nations like in Europe, they have 13 spots. And so the probability is much, much higher."
Ghana sought to avoid FIFA action on Monday, saying it would immediately lift a temporary halt of league soccer imposed last week after police raided the football association in a tax and fraud probe.
South Korea have only one point after drawing their opening game against Uruguay and must beat Portugal to have any chance of progressing.
'They are the best team in the world and for us it is an honour to play them,' said Ratomir Dujkovic.
Portugal could qualify early for the next phase of the World Cup with a game remaining if they beat Uruguay on Monday, a task probably much easier said than done.
Kevin-Prince Boateng and Sulley Muntari put Ghana in the Champions League spotlight as they scored the goals which gave AC Milan a shock 2-0 win over Barcelona on Wednesday.
David Villa and Wesley Sneijder, with five goals each, head the list of the goal scorers at the 2010 World Cup.
